单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,弥散性血管内凝血,Chapter 11,中山医学院病理生理教研室,邓宇斌,弥散性血管内凝血 Chapter 11中山医学院病理生理,1,DIC,一、DIC原因和发病机制,二、促进DIC发生发展的因素（诱发困素）,三、DIC的分期和分型,四、DIC的功能代谢变化（病理生理变化）,五、DIC防治的病理生理基础,DIC,2,第一节 概述,1.血液的凝固与抗凝,流动性,血液运输载体,方向性,内（,）,凝血系统,凝血 外（,）,血小板：粘 聚 释,第一节 概述1.血液的凝固与抗凝,3,凝,抗凝,栓塞,失衡,凝,抗凝,出血倾向,2.DIC的概念,出血,病因 微血栓 后 休克,致凝 继发纤溶亢进 果 栓塞,溶血,120种病：感染、肿瘤、产科意外,凝抗凝 栓塞,4,Introduction,DIC is characterized by the,activation of the coagulation,system with resultant,consumption of a variety of,coagulation proteins and platelets,which results in hemorrhagic,diathesis and ischemic injury to,various tissues.,Introduction DIC is c,5,1.Blood Coagulation,It is propagated by an,enzymatic events termed,coagulation cascade.,Contact factors and the intrinsic pathway,Tissue factor and extrinsic pathway,1.Blood Coagulation,6,2.Fibrinolysis,It is the result of the action,of plasmin,a proteolytic,enzyme produced from an inert,plasma precursor(plasminogen),by the action of various,substances termed,plasminogen activators.,2.Fibrinolysis,7,Humoral plasminogen activators,Tissue plasminogen activators,Fibrin or fibrinogen degradation products,FDP,(Significant biological activity),Fragments X,Y and E,(potent antithrombins),Fragments Y and D,(inhibit fibrin polymerization),Humoral plasminogen activators,8,a a a,PC APC,TM+灭 活,PS(+),C4b,C4b PS(-),9,酶,纤溶,FDP,酶,AT,PC,抗,APC TM+a,凝,PS,PGI,2,VEC,TM,10,第二节 DIC的病因发病学,一、发病原因及机理,1.VEC广泛受损,原因,感染,炎症、免疫损伤（抗磷脂综合征）,高低温、放射损伤,缺血缺氧,酸中毒,第二节 DIC的病因发病学一、发病原因及机理,11,Etiology of DIC,1.acute DIC,(1)septicemia (2)severe trauma,(3)obstetric accidents (4)shock,2.subacute DIC,(1)malignant tumors,(2)retained dead fetus,3.chronic DIC,(1)giant hemangioma,(2)systemic lupus erythematosus(SLE),Etiology of DIC1.acute DIC,12,机理,胶原暴露,凝,VEC 释放,受损 合成PGI,2,TXA,2,抗凝,表达TM,APC,机理,13,2.血细胞大量受损,RBC受损,感染：疟疾,原因：溶血 G6PDase：蚕豆病,免疫损伤：异型输血,红细胞素（）,机理：释,ADP,P聚集,2.血细胞大量受损,14,WBC激活或受损,坏死,白血病细胞,释,原因 化疗受损,机理,炎症激活,合成、释,（内毒素、补体、LC、P、AgAb）,WBC激活或受损,15,P激活或受损,原发性：免疫损伤（抗P抗体抗磷脂抗体）,继发性：DIC 粘（GP,b胶原）,聚（GP,ba fg）,TXA,2,等 P聚、血管收缩,机理,PF,111,提供“反应面”,aCa,2+,a aCa,2+,a,PF,3,PF,3,P激活或受损,16,3.大量致凝物质入血,肿瘤细胞,坏死（包括产科意外）,组织细胞,带负电颗粒物质（内毒素）a,胰蛋白酶,其它丝氨酸蛋白水解酶 a,蝰蛇毒,3.大量致凝物质入血,17,Pathogenesis of DIC,1.extensive damage of vascular endothelial cells,Intrinsic clotting cascade,2.severe tissue injury,Extrinsic clotting reaction,Pathogenesis of DIC 1.extensiv,18,3.excessive destruction of the circulating blood cells,Generation of procoagulant-active substances,Intravascular coagulation,4.other thromboplastic materials entering the blood,Activation of clotting system through the contact of blood with an abnormal surface,3.excessive destruction of the,19,the net effects are summarized as follows:,1.loss of plasma fibrinogen as it is consumed by the clotting process and by the action of plasma.,2.loss of other clotting factors notably,and,as they are used up during the operation of the clotting cascade.,3.fall in the platelet count,as the platelets aggregate and leave the circulation.,4.appearance of fibrin degradation products,as plasmin acts on its substrates.,the net effects are summarized,20,二、诱因与发生机理,消除致凝物质功能,血液凝血活性,抗凝活性,1.单核吞噬细胞系统功能,内毒素血症、糖皮质激素、脾,消除功能,：致凝物、,a,、凝纤产物,二、诱因与发生机理,21,2.肝功能严重障碍,灭活活化凝血因子,合成AT,、PC,枯否细胞吞噬功能,3.,血液的高凝状态,凝血活性 凝血物质：怀孕、肿瘤、应激,抗纤溶：胎盘、药,抗凝活性 抗肝素：H,AT、PC、TM等,4.,血流郁滞,2.肝功能严重障碍,22,Predisposing factors to DIC,1.impairment of the clearance mechanism.,2.hypercoagulable state.,3.disorder of microcirculation.,Predisposing factors to DIC1.i,23,第三节 DIC的分期及分型,高凝期,分期,消耗性低凝期,继发性纤溶亢进期,急性,按发病速度 亚急性,分,慢性,型,代偿型,按代偿情况 失代偿型,过度代偿型,第三节 DIC的分期及分型,24,Types of DIC,1.acute DIC,Multiside bleeding diathesis,Thrombotic complications usually,Severe bleeding lead to shock and severe ischemic change in organs,2.subacute DIC,Rarely bleeding,The evidence of DIC can be detected by laboratory examinations,3.chronic DIC,Types of DIC,25,Stage of DIC,1.hypercoagulable stage,2.hypocoagulable stage,3.secondary fibrinolytic stage,Stage of DIC1.hypercoagulable,26,第四节 临床表现,1.出血,凝血物质消耗性,酶：破坏凝血因子,继发性纤溶亢进,a,FDP抗凝：竞争性抑制,a,P聚,血管壁受损及溶栓,第四节 临床表现1.出血,27,Consequences of DIC,1.disturbance of coagulation-bleeding,(1)the consumption of clotting factors and platelets,(2)the activation of fibrinolytic system,(3)the production of fibrin degradation products(FDPs),Consequences of DIC 1.disturba,28,2.休克,出血,回心血量,微血栓阻断通路,CO,心泵功能,:心肌DIC,BP,右心后负荷,:,肺DIC,外周阻力,:,四个酶系统激活,A、B肽,扩血管物质 FDP,(通透性)激肽,C,3a,、C,5a,29,2.disturbance of circulation-shock,Microthromobus in capillariesand venules,Blood returning decrease,Cardiac muscle damage,Cardiac output and blood volume reduce,Effective circulating blood volume decrease,Hypotension,2.disturbance of circulation-,30,3.栓塞,微血栓 器官 功能,BP,供血 障碍,4.溶血,：微血管病性溶血性贫血,3.栓塞,31,3.ischemic tissue damage-dysfunction of multiple organs,Renal insufficiency,Acute adrenal failure,Pituitary necrosis,Adult or acute respiratory distress syndrome(ARDS),Convulsion and coma,3.ischemic tissue damage-dy,32,4.microangiopathic hemolytic anemia(MHA),characteristic morphologic abnormality of the red blood cell