Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,*,Synthetic vs.Bio-IdenticalHormones,Richard Adelman MD,Natural:definitions.,1.In accordance with what is found or expected in nature.,2.Produced or existing in nature;real;not artificial or manufactured.,(Nature is neither good nor bad.It,can be exhilarating or excruciating.),Where do replacement hormones come from?,Almost all hormones are made from soy beans.It used to be Mexican yams.,Some still comes from pregnant horse urine.Premarin.,Steroid Hormones small changes make big differences,How can you call it bio-identical if it is synthesized from soy beans in a lab?,It is natural or bio-identical because it is exactly the same as the molecules made by and used by the human body.Def#1,not#2.,Our bodies manufacture steroid hormones from cholesterol.Labs manufacture identical hormones from sterol rings found in soy.,Its the,sameness,of the molecules that is important,the body doesnt know the difference.Synthetic or foreign steroids can also be made from soy and often are.,Bio-identical Hormone Replacement,Richard Adelman MD,OB/GYN,in Panama City since 1984,Phlebology,=Vein Specialist since 2004,Cosmetic Procedures,:skin rejuvenation,laser hair removal,botox,fillers,liposuction,spider veins,Law School,finished 1996,Why are you here?2-11-09,First Suzanne Somers,and now Oprah Winfrey have sung praises for bio-identical hormones for menopause.“For two years,Oprah suffered from menopausal symptoms and a low thyroid condition.She wasnt herself,and doctors she had no answers.Three days after starting bio-identical hormones,her menopausal problems were gone and she was singing praises.,“,Thanks for the media buzz,Bio-identical hormone use has enjoyed growing popularity for 15 years.,Pioneered by Dr.John Lee and Dr.Joel Hargrave and many others.,Given a boost by the 2002 WHI study that destroyed any confidence in synthetic hormones.,BIO-IDENTICAL HORMONES?,I was introduced to bio-identical hormones for menopause by Dr.Randolph in Jacksonville 5 years ago.,That initial view has widened over the years to include thyroid and adrenal problems as well as men.,Two Goals Today.,1.To show the logic of using the same hormones for replacement as those that the body makes and recognizes.,2.To consider the value of hormone replacement when hormones fall as part of the aging process-to improve quality of life and promote healthy metabolism.(the opposite of disease),Warning science slides ahead,Increasing knowledge about how hormones act and interact with each other are changing how we view their role in aging and illness.,Bio-identical hormone replacement is worthless if it is a marketing gimmick,a cool trend or“alternative.,So the science is important(and explains the superior results).,Hormones are more than hot flashes.,LIFE=Metabolism.,Metabolism,is the set of,chemical reactions,that occur in living,organisms,in order to maintain,life,.These processes allow organisms to grow and reproduce,maintain their structures,and respond to their environments.,Tear Down and Build Up,Catabolism,breaks down organic matter,for example to harvest energy in,cellular respiration,.,Anabolism,on the other hand,uses energy to construct components of cells such as,proteins,and,nucleic acids,.,Hormones are control signals that often work by regulating enzymes,The chemical reactions of metabolism are organized into,metabolic pathways,in which one chemical is transformed into another by a sequence of,enzymes,.,Enzymes also allow the,regulation,of metabolic pathways in response to changes in the,cells,environment or,signals,from other cells.,Hormones and Homeostasis,As the environments of most organisms are constantly changing,the reactions of metabolism must be finely,regulated,to maintain an ideal set of conditions within cells,a condition called,homeostasis,.,Hormones play important roles in this regulation.,Long distance communication;Hormones are messengers,Many cell signals are carried by molecules that are released by one cell and move to make contact with another cell.,Endocrine,signals are called,hormones,.Hormones are produced by endocrine cells and they travel through the,blood,to reach all parts of the body.,Summary:,Hormones are part of our bodies control mechanisms.,They help the body to deal with a changing environment by regulating our metabolism toward an optimal state.,Hormones bring the message by binding or fitting into a receptor.,ANALOGY:,Hormones are keys.,Bio-Identical hormones are the correct keys.Altered hormones are imperfect keys.,Receptors are locks.,Our bodies can only make natural receptors and will not begin to make altered receptors because we take altered hormones.,Hormone Receptor,Usually,only one hormone can fit in a receptor and turn it on strongly each hormone/receptor pair is unique.,A progesterone receptor typically binds progesterone for a short time.It directs the activity of specific enzymes th