Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,*,Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,Klik for at redigere i masteren,Klik for at redigere teksttypografierne i masteren,Andet niveau,Tredje niveau,Fjerde niveau,Femte niveau,*,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,*,*,2013 Aerocrine Inc.,EMD-000643-00,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,*,2013 Aerocrine Inc.,EMD-000643-00.,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,*,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,*,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,*,*,2013 Aerocrine Inc.,EMD-000643-00,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,*,2013 Aerocrine Inc.,EMD-000643-00.,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,*,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,*,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,*,*,2013 Aerocrine Inc.,EMD-000643-00,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,*,2013 Aerocrine Inc.,EMD-000643-00.,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,*,Click to edit Master title style,Click to edit Master text styles,Second level,Third level,Fourth level,Fifth level,*,呼出气一氧化氮(,FeNO,)在临床中的应用,课件,课件,NO,内源性调节分子,合成由一系列酶调节,NO,合成酶,呼出气中的,NO,主要由支气管壁上皮细胞生成,(过敏性)炎症性气道疾病往往伴随呼出气,NO,的增高,通常和嗜酸性炎症相关,IFN-,NO,iNOS,STAT-1,(Homeostatic,source unknown),Corticosteroid-resistant mechanism,Soluble mediator,Asthma,Healthy,NO,iNOS,STAT-6,IL-4/IL-13,(Th2 cells,mast cells,eosinophils),Corticosteroid-sensitive mechanism,Air pollution(oxidative stress),NO,NO,iNOS,AP-1,Mucus,AHR,Allergen exposure,EMD/000585/00,NO 内源性调节分子IFN-NOiNOSSTAT-1(H,FeNO,是一种诊断和监测炎症性气道疾病的重要标志物,一氧化氮由人体自身产生,炎症发生时升高,与嗜酸性粒细胞炎症相关,对,FeNO,研究的文献已超过,3000,篇,所有主要的制药公司在其呼吸道药物临床研究中进行,FeNO,检测,美国变态反应、哮喘和免疫学会,(AAAAI),和过敏