Click to edit Master title style,Click to edit Master text styles,Second level,Third level,University of Ottawa-Bio 4118 Applied Biostatistics,Antoine Morin and Scott Findlay,*,BIO 4118 Applied Biostatistics,Scott Findlay,GNN 374(Biology);555 King Edward(Institute of the Environment),(613)562-5800 x 4549(Biology),(613)562-5874(Institute of the Environment),1,About me,Not a statistician!,So emphasis will be on practical knowledge and application of statistics,rather than theorems and proofs.,2,Why you should be here,you have an interest in statistical reasoning,you have a desire to learn to use statistics properly in experimental design and data analysis,you want to develop your ability to critically assess scientific(or pseudo-scientific)arguments,3,What is expected of you,attendance at most lectures,attendance at most laboratory sessions,feedback to me on what you like and dislike about the course,and especially how it might be improved,4,Objectives,Understand the fundamental principles of statistical inference.,Understand the general principles underlying the most common tests.,Know the assumptions of common tests and understand impact of violations.,Be able to perform standard statistical analyses with S-PLUS.,5,Evaluation,50%Problem assignments,50%Term projects,All assignments are“open-book,and can be done in groups of three people or fewer.,Remember,plagiarism is not acceptable!,6,Morin,A.&C.S.Findlay 2004.,Course Notes for BIO 4118 Applied Biostatistics.,University of Ottawa,Ottawa,available at Agora for about$15.,Findlay,C.S.&A.Morin 2004.,Lecture Presentations for BIO 4118 Applied Biostatistics,University of Ottawa,Ottawa.Posted on web site as individual files.,Zar,J.H.2000.,Biostatistical Analysis,(4,th,edition),Prentice-Hall,Upper saddle River,New Jersey.$107 at Agora,135 1/2 Rue Besserer St.,Texts,7,Class preparation,Read appropriate chapter(s)in lecture notes beforehand,and bring questions to class,.,If youve got a question,ask it immediately!There is no such thing as a stupid question!,For labs,read appropriate section(s)in lecture notes beforehand.,8,Accessing the course web,Bio 4118/4518/8100s Documents,Biostatistics/2006 lecture notes,solutions,Class presentations(Acrobat and ppt),Previous problems and exams with solutions,Messages(Whats new?),9,Some opinions of statistics,“There are three types of lies:lies,damn lies,and statistics!,Benjamin Disraeli,“If your experiment needs statistics,you should have done a better experiment.,Ernest Rutherford,10,Some opinions of statistics,“,To call in a statistician after the experiment is done may be no more than asking him to perform a postmortem,“The purpose of models is not to fit the data,but to sharpen the questions.,Samuel Karlin,examination;he may be able,to say what the experiment,died of.,Sir Ronald Fisher,11,What statistics can and cant do,provide objective criteria for evaluating hypotheses,synthesize information(not without information loss keep your raw data!),help detect patterns in messy data,help optimize effort,help you critically evaluate arguments,tell the truth(probabilistic conclusions only!),compensate for poor design,indicate biological significance:statistical significance,does not,mean biological significance,nor,vice versa,!,Can,Cant,12,The four ages of a biostatistician,Age,Defining characteristics,Comment,Stone,Total ignorance,Ignorance is not bliss!,Bronze,Nodding familiarity,but understanding purely superficial,Statistics a(small)sidebar to scientific investigation(See Rutherford,Ernest),Silver,Moderate familiarity coupled with a strong desire to demonstrate same;statistical reach exceeds grasp,Overwhelming concern with statistical minutae;scientific forest often obscured by statistical trees.,Gold,Knows when statistical issues are(and are not)important;recognizes limitations(of self and statistical science),That to which we can/should all aspire.,13,