单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,*,“非诚勿扰”与,恶性黑色素瘤,“非诚勿扰”与,1,catalogue,What is malignant melanoma?,Melanoma triggers and causes,Primary sites,Clinical characteristics,Early clinical performance,Late-stage clinical manifestations,Pathological type,Treatment,2019 melanoma field progress review,catalogueWhat is malignant mel,2,What is malignant melanoma?,Malignant melanoma,also known as melanoma,is the origin of epidermal melanocyte or nevus of malignant tumors.The disease can be seen at any age,more seen in middle-aged and older,women slightly more than men.,What is malignant melanoma?Mal,3,Melanoma triggers and causes,Air pollution,To pursue beauty,The lack of medicine knowledge,Immune deficiency,Abusing the estrogen drugs,Malignant transformation of black mole,Racial genetic factors,Trauma and chronic stimulation factors,Melanoma triggers and causesAi,4,Air pollution,Harmful ultraviolet light and some harmful material in the air make a difference of human skin,causing melanocyte abnormal expression,trigger melanoma.,Air pollution Harmful ultrav,5,Many people in order to pursue the clean skin to use chemical,cosmetics,skin pollution caused by chemical,even someone with chemical mordant purify skin a mole,stimulates the excessive proliferation melanocyte.,To pursue beauty,Many people in order to pursu,6,Racial genetic factors,Malignant melanoma occur in the white race.,For the incidence of world each year to less than 1 2/10 million,but Australias Queensland annual incidence of 16/10 million population,it is the worlds leading high incidence of malignant melanoma.,Africa and Asian people rarely have the sickness.,Racial genetic factorsMalignan,7,Primary sites,Malignant melanoma 90%occurs in the skin,the most common in the back,metal-studded,leg,foot,toe,nail bed,scalp and so on;a few occurs in vulvae,digestive tract and eyes.,Primary sitesMalignant melanom,8,Eye lesionsand Oral lesions,脉络膜黑色素瘤,口腔黑色素瘤,Eye lesionsand Oral lesions脉络,9,Generally speaking moles surface is smooth,melanoma of surface is coarser.If the surface is smooth,and suddenly becomes coarse or,we should pay attention to it.,Clinical characteristics,Generally speaking moles sur,10,Ulceration not only is one of the important melanoma clinical manifestations which is different from mole,but also has the meaning of prognosis than no ulcer.,Patients of malignant melanoma generally are the old;the youth or children melanoma are rare.,Ulceration not only is one of,11,Early clinical performance,Color:a mole increase in size,pigment or darker or lighter,a mole deepen,shiny,appear color changed.,Edge:a mole to radiate out in moles expansion,appear around uneven indented change;become irregular or appear satellite form small a mole,or several birthmark fusion,the surface concavo-convex inequality.,Surface:rough;Often coarse and accompanied by scale form or flake desquamation.Sometimes have the drainage or ooze blood,higher lesions can face.,Early clinical performance Col,12,Lesions surrounding skin:can appear edema or lose skin gloss or become white,gray.,Kakesthesia:a mole without itching or discomfort pain.,regional lymph node enlargement,faintly visible blue-black,.,早期临床表现,Lesions surrounding skin:can,13,Late-stage clinical manifestations,Special type：a small nodular lesion site,the boundary clear,no coated,tan-white or grey-blue,quality of a material is solid.,Freckles type:more from the primary lesions malignant freckles;surface was flat;the edge great irregularity;the epidermis of tumor block with freckles samples,this type often occur on elderly facial freckles lesions,which is relatively rare.,Late-stage clinical manifestat,14,Spread type:its appearance is shallow eczema kind,and its jagged edge is irregular,with black,grey and pink disorderly color on the surface.,Nodular type:tumor nodules are out of the skin surface;the color is dark brown,gray red and rarely colorless.Bump surface is shown more cauliflower shape,polypoid or bacteria shape,often happen ulcers,.,Spread type:its appearance,15,Pathological type,Superficial expandable type:about 70%,it is visible at surface anywhere;go along the surface to expand,and then expand to the depth,called the vertical development.,Pathological typeSuperficial e,16,nodular type:about 15%,vertical development;penetrate to subcutaneous tissue;prone to lymph node metastases;even more deadly.,nodular type:about 15%,vertic,17,Ephelides type:about 5%,it primary occur in old people facial skin where black freckles long stand;this type do horizontal growth and enlarge 2cm 3cm or more around.,非诚勿扰与恶性黑色素瘤ppt课件,18,Extremity black mole type:,about 10%,that happens at palms,foot,nail bed and mucous membranes.,Extremity black mole type:,19,Treatment,Surgical treatment:,early circumscribed primary foci should be carried out extensively;the scope should be apart from the primary foci 3,5cm;the primary foci should be excised to subcutaneous tissue and muscle membrane;when touch the lymph node enlargement,generally