单击此处编辑母版标题样式,单击此处编辑母版文本样式,二级,三级,四级,五级,*,*,单击此处编辑母版标题样式,单击此处编辑母版文本样式,二级,三级,四级,五级,从高血糖与糖尿病周围神经病变的关系反思研究和控制策略,北京大学人民医院 纪立农,趁使人跺僧瓢减漏圭惕旅窃洋稳氯栅尿涤胶决施纸懊放隙暂凹逆犀厘绥憾纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略,从高血糖与糖尿病周围神经病变的关系反思研究和控制策略北京大学,1,China Cardiometabolic Registries,2,Nation-wide,prospective,registry series,designed to better understand clinical outcomes of current treatment of cardiovascular and metabolic diseases in real world settings,Organized by Chinese Medical Doctor Associations,Supervised by CCMR International Advisory Board,Managed by VitalStrategic Research Institute,China Cardiometabolic Registries,芬适硒吸宽趁篮盘伺啥慕钡九未臆各墟聪替瑞蛮撼矾窖曲苯搐条檬衬对存纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略,China Cardiometabolic Registri,2,研究者会议2011 年 5 月 14-15 日,中国2型糖尿病患者心血管疾病危险因素的纵向队列研究,中国老年学学会（,GSC,）主办,中国医师协会心血管内科医师分会,(CCCP),协办,中国医师协会内分泌及代谢科医师分会,(CEA),协办,中国心血管代谢病系列研究(CCMR)组织及专家委员会,指导,华斯泰生命策略研究所/上海华斯泰医学咨询有限公司,(VSRI),执行,默沙东,(,中国,),有限公司赞助,Nationwide Assessment of Cardiovascular Risk Factors-Blood Pressure,Blood Lipid,and Blood Glucose in Chinese Patients with Type 2 Diabetes,Linong Ji Peking University Peoples HospitalOn behalf of CCMR Advisory Board,Ji et al.AJM，2013，in press,潜胚钉矽坞沃鳖俺卜弱趋嘘按赘啥索醒龋揉秸藩趴寒亦刘鉴盏哆剧甥蔽挥纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略,研究者会议2011 年 5 月 14-15 日中国2型糖尿,3,Study Objectives Primary,Primary Objective,To assess the level of control of CVD risk factors,including blood pressure,blood lipid,and blood glucose,in outpatients with type 2 DM in 6 representative regions in China and in three tiers of hospitals,To identify the gap between real world diabetes management situation and standard of care,4,Ji et al.AJM，2013，in press,答脱庚桥应宋课捏娇宴枣字菌蜀蹦你旋干柯率践彬倪后硅射试赡耶倒芥狙纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略,Study Objectives PrimaryPrim,4,Study Objectives-Secondary,Secondary Objectives,To assess the proportion of microvascular and macrovasclar diabetic complications in outpatients with type 2 DM,To assess real-life treatment patterns in outpatients with type 2 DM,To assess the proportion of hypoglyecemia under the current treatment,To assess the influencing factors(hospital classification,regional distribution,medical history,educational level and others)on DM treatment outcomes,5,Ji et al.AJM，2013，in press,琵饲花谬移曼态炽岁裙戊补撅歉赋凑且加醉前惠夜尺舒彩怯氮捂杖彼姆相纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略,Study Objectives-SecondarySe,5,Non-interventional,observational,cross-sectional design,Type 2 diabetes diagnosed for 6 months or longer,Ambulatory patients from endocrinology,cardiology,nephrology clinics in all 3 tiers of hospitals(Tier 1,2,and 3)located in all 6 main regions in China,Estimated sample size was 25,000 patients in order to have sufficient power to detect the difference of the primary assessment in each region,6,6,6,Study Design,Targeted to enroll 25,000 patients,Ji et al.AJM，2013，in press,霍勘显添肥撰朱垛讹烽戎廖巫戎挟圣冶执合找涕结摧犀孤贿并层脉来寨哎纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略,Non-interventional,observatio,6,Distribution of Participating Hospitals,7,Number of sites in each region was proportional to the population in the region,National Regions,Tier 1,Tier 2,Tier 3,SUM,North East,4,6,6,16,North,4,6,8,18,East,5,7,6,18,North West,4,5,5,14,South West,5,9,7,21,Central South,4,5,7,16,SUM,26,38,39,103,Ji et al.AJM，2013，in press,哮洪腰拎愚诧哥粳舷继摇嘴垂温虫钦谓圆竣缓在纹侄勉偶朗延逢涨手辅前纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略,Distribution of Participating,7,Characteristics of study subjects,8,Number,Percentage(%),All,25454,100.0,Age(yr),65,11599,45.5,Gender,Male,11955,47.0,Female,13499,53.0,Resident,Urban,22776,89.5,Rural,2678,10.5,BMI(kg/m,2,),24,14835,58.3,Mean age=62.6+/-11.9 years,Ji et al.AJM，2013，in press,蚕谗驯烷弗欧关郁膝嘘籍潭喘狐句拆百酵墩颐戚闺做帕砰媳红痒物袖砧牢纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略,Characteristics of study subje,8,Distribution of CVD Risk Factors,28%of the patients had T2D only,60%of the patients also had HTN(T2D+HTN),About 42%of the patients also had DYLP(T2D+DYLP),About 30%of the patients had“3B”:high blood glucose,blood lipid,and blood pressure(T2D+HTN+DYLP),9,T2D=type 2 diabetes,HTN=hypertension,DYLP=dyslipidemia,Ji et al.AJM，2013，in press,走杠呵痰肥灌曾巩泅磷蒸频稳炭彤领歌薪亡超沧纂前帮揉耽硷篇怠茵唐陇纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略,Distribution of CVD Risk Facto,9,Diabetes Duration and Complications,10,Prevalence of diabetic complications is proportional to duration of diabetes,(%),Duration of Diabetes,Ji et al.AJM，2013，in press,浊炉跌类芽帕渔韶莉苔叭门搞舵狈擂代询恬提皇服即概净琉饲爸乍杖芜韶纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略,Diabetes Duration and Complic,10,Diabetic Complications and CVD Risk Factors,11,(%),Ji et al.AJM，2013，in press,泽郭游釉叮献刮楚藐剧现肘蘸篙约在腺成止敏吏诉仁酵柞渣货侠栽佰欢神纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略,Diabetic Complications and CVD,11,Callaghan BC,，et al.,Cochrane Database Syst Rev.,2012,幢宪枯狈晃锦咏蚕藻甥菌减需那跪缺侯扑输沉葬遂启鳞醚淘青茂洋眼帝着纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略纪立农-从高血糖与糖尿病周围神经病变的关系反思研究和控制策略,12,Callaghan BC,，et al.,Cochrane Databa