,*,单击此处编辑母版标题样式,单击此处编辑母版文本样式,第二级,第三级,第四级,第五级,临床麻醉学Clinical Anesthesiology绪论Introduction,The term“anesthesia(麻醉)is derived from Greek Word,it means“lack of feeling or sensation or“privation of senses im plying,lack of appreciation.The usual concept for anesthesia relates primarily to the prevention of pain perception during an operation or an invasive procedure.But,this concept is out of date now.,In general,anesthesia can be defined as a drug-induced or physical factors-induced state of reversible functional depression of part of the central nervous system or peripheral nervous system,which is characterized by loss of sensation,especially pain perception.,The increasing complex nature of operations sparked the development of anesthesia.Advance in related basic science especially in research in anesthesia per se,and the development of new agents,adjuvants,eguipments,technigues and capacity of sustaining life had changed and broadened anesthesia into a discipline concerned with more than relief of pain.over the past 56 decades,anesthesiology(麻醉学)has emerged as a clearly defined specialty and firmly established.,The evolution of modern anesthesiology may be devided into 3 stages:1、麻醉anesthesia 2、临床麻醉学(Clinical anesthesiology)3、麻醉与危重病医学(anesthesiology and critical care medicine)department of anesthesiology and resuscitation department of anesthesiology and critical care medicine.,一、麻醉学开展简史,(The history of anesthesia),1、Ancient times,1Acupuncture analgesia 475221 B.C.,2华陀(141203)麻沸散,3Ancient Egyptians used The combination of opium poppy and hyoscyamus,4The Incas may be the earliest to use local anesthesia.,2、Modern anesthesiology,1Inhalational Anesthesia (吸入麻醉),1844 Horace wells N2 0(氧化亚氮),1846 William T.G.Morton Ether(乙醚),1847 James Simpson chloroform(氯仿),1920 Arthur E.Guedel was the first to elaborate,on the signs of general anesthesia,Magill Endotracheal intubation(气管内插管),1927 Ralph waters sodalime(钠石灰),1956 halothane (氟烷),1972 enflurane (恩氟烷),1981 isoflurane (异氟烷),1990 sevoflurane(七氟烷),1992 desflurane (地氟烷),2Intravenous anesthesia(静脉麻醉),1934 Lundy 和waters thiopental (硫喷妥钠),benzodiazepines (苯二氮卓类药),diazepam 地西泮 1959,midazolam (咪达唑仑)1976,others:,sodium hydroxybutyrate,r-oH(羟丁酸钠)1960,ketamine (氯胺酮)1970,etomidate (依托咪酯)1972,propofol (丙泊酚)1983,(3)opioids,fentanyl (芬太尼),sufentanil (舒芬太尼),alfentanil (阿芬太尼),remifentanil (瑞芬太尼),(4)Muscle Relaxants (肌肉松弛药),1942 curare (箭毒),Succinylcholine (琥珀胆缄),Mivacurium (米库氯铵),Now,the relaxants in common use include,Vecuronium (维库溴铵),atracurium (阿屈库铵),Rocuronium (罗库溴铵),Cisatracuronium (顺式阿屈库铵),5Local and Regional anesthesia(局麻和区域麻醉),1884 Carl koller topical cocaine(可卡因表麻),1898 August Bier spinal anesthesia(脊麻、腰麻),1901 Ferdinand cathelin and Jean sicard caudal epidural anesthesia(骶麻),1921 Fidal pages and 1931 Achille Dogliotti Lumbar epidural anesthesia(腰部硬膜外麻醉),1904 Alfred Einhorn synthesized procaine,Other local anesthetics:,dibucaine(地布卡因，1930)，tetracaine(丁卡因 1932),lidocaine(利多卡因，1932)，chloroprocaine(,氯普鲁卡因,1955),mepivacaine(甲哌卡因,1957),prilocaine(丙胺卡因,1960),bupivacaine(布比卡因,1963),etidocaine(依替卡因,1972),The latest local anesthetics include ropivacaine(罗哌卡,因)and levobupivacaine(左旋布比卡因),Anesthesiologist prof Rovenstine,established the first pain clinic,1970 In USA,society of critical care,medicine formed(美国危重病学会成立),(6)Since the eighties of last century until now the clinical anesthesiology is characterized by emphasizing anesthetic monitoring and paying more attention to anesthetic safety.,The minimum standards for intraoperative monitoring have beenadopted by the ASA(American society of Anesthesiologists)include:,Body temperature(体温),Arterial blood pressureand heart rate,Electrocardiography(ECG)(心电图),Pulse oximetry(S,P,O,2,，脉搏氧饱和度),End tidal carbon dioxide(呼气末二氧化碳),For other monitoring methods,you may choose it when it is necessary.,二麻醉学专业的任务和范围,(The scope and task of Anesthesiology),The scope and basic tasks of anesthesiology include:,1.Clinical anesthesiology,(1).To perform preanesthetic visit and evalualion,and to formulate anesthetic plan.Taking part in the preanesthelic preparation.,(2).To render patients insensible to pain and discomfort and keep the stress responseat suitable level.,(3).To monitor the patients during operations,and to regulateor control the importaut physiological functions of the patients in order to provide maximum safety for the patients and to provide optimal operative conditions for surgeons.,(4).To prevent and treat anesthetic complications,(5).To monitor and treat patients in postanesthesia care unit(PACU),2.First aid and resuscitation(急救与复苏),3.Critical care medicine(CCM,危重病医学),(intensive care medicine,也称加强医学),Its clinical position is called Intensive care unit,ICU(重症监测治疗病室或加强医疗病室),4.Pain management and its relatcd researeh epically the mechanism of pain,5.Research,teaching and training,三如何学好麻醉学,(How to learn anesthesiology),1.To combine basic medical sciences with clinical medicine(根底与临床结合),2.To combine theory with practice(理论与实践结合),Anesthesiologist o